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Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the <t>LegendPlex</t> NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.
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Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the <t>LegendPlex</t> NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.
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Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the <t>LegendPlex</t> NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.
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Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the <t>LegendPlex</t> NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.
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Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the LegendPlex NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.

Journal: Molecular Therapy Advances

Article Title: Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates

doi: 10.1016/j.omta.2026.201726

Figure Lengend Snippet: Cytokine expression profile after AAV gene therapy in NHPs Quantification of vitreous cytokines in NHP1 (A) and NHP2 (B) using the LegendPlex NHP Inflammation Panel with levels expressed as fold-change (log 2) in mean fluorescence intensity (MFI) relative to baseline. RE, right eyes; LE, left eye. (C and D) Single-cell transcriptomic analysis of cytokine gene expression among retinal cell types in NHP1 and NHP2, respectively.

Article Snippet: Data were analyzed in the LEGENDplex Data Analysis Software (Qognit, BioLegend).

Techniques: Expressing, Fluorescence, Single Cell, Gene Expression